Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases
Sabrina Sofia Burgener, Mark Thomas Milner, Shoumit Dey, Pooranee K. Morgan, Daniel G. Blackmore, Emmanuelle Frampton, Gregory C. Miller, Monalisa Duarte de Oliveira, Kirsten Myra Kenney, Rinie Bajracharya, Ulrich Baumgartner, Thomas J. C. Collins, Zherui Xiong, Quan Hoang Nguyen, Peter J. Meikle, , Kate Schroder
This study shows that CASP1 self-cleavage terminates its activity in vivo, maintaining homeostasis and preventing inflammasome-driven diseases.
bioRxiv · Apr 28, 2025 · PreprintImmunology