Rebecca J. Prest

This study shows that Mycobacterium marinum switches ESX-1 substrates in response to acidic pH, affecting phagosome lysis and bacterial survival.

This study investigates the relationship between EspE and EspF secretion and their regulatory functions in mycobacteria, finding that their secretion is separable from their gene regulatory roles.

This study identifies EspN as a critical transcription factor regulating the ESX-1 system in M. marinum, which is essential for macrophage infection and disease burden, but its activity is masked by EspM under laboratory conditions.