Chulan Kwon

CMAC estimates absolute transcriptional age of cardiomyocytes using deep learning, achieving high accuracy across multiple datasets and platforms.

SEME corrects aberrant splicing in iPSC-CMs by programmable microexon incorporation, restoring filamin C expression in a dilated cardiomyopathy model.

The paper develops a targeted proteomics method to quantify retinoid metabolism and signaling proteins across species and tissues, revealing tissue-specific networks and developmental changes in the heart.

This study shows that in vivo bioincubation of human iPSC-derived cardiomyocytes in neonatal rat and pig hearts promotes maturation to adult-like phenotypes with organized sarcomeres and mature morphology.

The paper investigates muscle loss as a key evolutionary step in turtle shell development using multi-modal imaging and histology-based deep learning to analyze turtle embryos.

This study shows that in vivo maturation of MLP-KO iPSC-CMs recapitulates DCM phenotypes, while in vitro maturation does not.

The paper shows that mesendodermal cells induced from mouse embryonic stem cells fail to contribute to heart formation when injected into blastocysts.

The paper identifies cardiac progenitors as a source of Wnts that regulate second heart field development through secretion, using genetic manipulation and single-cell RNA sequencing in mice.

PACNet enables platform-agnostic comparison of cell fate engineering protocols by analyzing transcriptomic data from multiple studies and identifying best practices and off-target effects.

The paper identifies universal gene pathways and regulators involved in organ maturation across four mouse tissues.

This paper describes a mouse model with 100% penetrance of AVSD by introducing conditional SHH pathway mutations in a trisomic DS model.

The paper develops a transcriptomic entropy metric to benchmark maturation of PSC-derived cardiomyocytes against endogenous tissue using scRNA-seq data.

This study shows noncanonical Notch signaling has stage-specific roles in cardiac development, inhibiting early heart formation but promoting later growth.

This study identifies PGC1/PPAR signaling and its regulators Yap1 and SF3B2 as key drivers of cardiomyocyte maturation through single-cell transcriptomic analysis across neonatal to adult hearts.

This paper demonstrates that mouse embryonic stem cells can generate heart-like structures with in vivo-like morphogenesis, supporting cardiovascular progenitors and early heart field compartments.

The paper integrates proteomic and genomic data from skeletal muscle myocytes to identify gene and protein expression differences between slow and fast-twitch fiber types.

The paper identifies lncRNA TSSs and designs sgRNA libraries for CRISPRi/a to study their transcription.