Simone Kunzelmann

This study develops BacPROTACs, a new class of antibacterial agents targeting M. tuberculosis, showing improved activity over traditional inhibitors.

This study uses cryo-EM to reveal structural intermediates of CSN-mediated SCF deneddylation, providing insights into the mechanism and potential for drug design.

This study characterizes the KHNYN ex-diKH domain's role in ZAP antiviral activity, revealing its structural features and identifying a potential protein-protein interaction site.

This study shows that PKG regulation in malaria parasites involves cGMP saturation and activation loop phosphorylation, with phosphorylation being essential for in vivo function.