Ether lipids influence cancer cell fate by modulating iron uptake
Ryan P. Mansell, Sebastian Müller, Jia-Shu Yang, Sarah N. Innes-Gold, Sunny Das, Ferenc Reinhardt, K. J. Sigmund, Vaishnavi V. Phadnis, Zhengpeng Wan, Jillian R. Stark, Daehee Hwang, Fabien Sindikubwabo, Laurène Syx, Nicolas Servant, Elinor Ng Eaton, , Whitney S. Henry
This study shows that ether lipids in cancer cells regulate membrane properties to influence iron uptake, ferroptosis, and metastasis, offering a therapeutic target.
Nature Communications · Jan 27, 2026Peer-reviewedCancer Biology