Matthew Sonnett

Protein accumulation upstream of Cdk1 activation regulates the competence and the timing of meiosis resumption

The paper shows that protein accumulation upstream of Cdk1 activation regulates meiosis resumption timing and competence in oocytes through stepwise acquisition of regulatory mechanisms.

Unbounded Cell Growth and Proteome Imbalance in Doxorubicin-Induced Senescent RPE-1 Cells

This study shows that doxorubicin-induced senescent RPE-1 cells exhibit unbounded growth and proteome imbalance, revealing dynamic regulatory mechanisms rather than passive arrest.

Using regularized regression and biological covariation to impute missing values in quantitative proteomics

The paper introduces a method to impute missing proteomics data using regularized regression and biological covariation, achieving high accuracy across multiple measurement modalities.

Transitions in the proteome and phospho-proteome during early embryonic development in Xenopus

The paper analyzes proteome and phospho-proteome changes during Xenopus embryonic development, identifying key transitions in protein expression and phosphorylation patterns.

Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

This study uses phosphoproteomics to analyze protein phosphorylation during Xenopus oocyte meiotic divisions, revealing key phosphorylation events and their roles in meiotic processes.

Diverse microtubule-destabilizing drugs induce equivalent molecular pathway responses in endothelial cells

This study shows that three MT-destabilizing drugs induce similar molecular responses in endothelial cells, suggesting clinical differences arise from pharmacokinetics rather than molecular mechanisms.

Synergy Between TNFα and Proteostatic Stress Drives Cell Death and Guard Immunity

The paper shows TNF synergizes with proteostatic stress to induce cell death and guard immunity against viral infection.

Accurate, Sensitive, and Precise Multiplexed Proteomics using the Complement Reporter Ion Cluster

The paper introduces TMTc+, a proteomics method that improves accuracy, sensitivity, and precision of multiplexed measurements compared to existing approaches.