Catherine Jessus

This study identifies Cyclin B2 as a PKA substrate that phosphorylation at S271 represses Cdk1-Cyclin B activation, maintaining G2-arrest in vertebrate oocytes.

The paper shows that protein accumulation upstream of Cdk1 activation regulates meiosis resumption timing and competence in oocytes through stepwise acquisition of regulatory mechanisms.

This study uses phosphoproteomics to analyze protein phosphorylation during Xenopus oocyte meiotic divisions, revealing key phosphorylation events and their roles in meiotic processes.