Divergent Retrograde Signaling Pathways Coordinate Longevity and Metformin Responses in Complex I and Complex IV Deficient C. elegans
Chutipong Chiamkunakorn, Juthakorn Poothong, Kongtana Trakarnsanga, Bart P. Braeckman, Wichit Suthammarak
This study shows that Complex I and Complex IV deficiencies in C. elegans activate distinct retrograde signaling pathways for longevity and metformin response, challenging the uniformity of mitohormesis.
bioRxiv · Sep 17, 2026 · PreprintCell Biology