Author

Valeria Visconte

Cleveland ClinicORCID 0000-0002-2993-1509Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Aaron D. VinyiD· 2 shared Eno-obong Udoh· 2 shared Jane Jialu XuiD· 2 shared Jaroslaw Pawel MaciejewskiiD· 2 shared Viviana ScocaiD· 2 shared Zachary Brady· 2 shared Abishar Cherukuri· 1 shared Albert Son· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

Aaron D. VinyORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Persistent Malignant Stem Cells Drive Relapse After Transplantation in the Myelodysplastic Neoplasms

Benjamin R. Kroger, Roni Tamari, Carmelo Gurnari, Yuanyuan Ji, Yazan F. Madanat, Yi Huang, Reiko Tachibana, Toby Thomas, Albert Son, Peter Carlsgaard, Clayton W. Jackson, Vivian Irizarry-Gatell, Alejandro Mariños, Zachary Brady, Prapti Arvind Patel, , Stephen S. Chung

The paper detects malignant hematopoietic stem cells (HSCs) in myelodysplastic neoplasms (MDS) using low-input sequencing and shows they predict relapse after transplantation.

bioRxiv · Oct 29, 2026 · PreprintCancer Biology

Multi-hit STAG2 mutations define a high-risk subset of MDS and reveal convergent evolutionary targeting of cohesin

Eno-obong Udoh, Yi Chen, Matteo D’Addona, Edna M. Stewart, Rong Deng, Felipe de Almeida Sartori, Serhan Ünlü, Zachary Brady, Ruowei Zhu, Xiaoyi Cheng, Viviana Scoca, Jane J Xu, Sergei R. Doulatov, Karl S. Theil, David S. Bosler, , Aaron D. Viny

The paper identifies multi-hit STAG2 mutations in MDS patients, showing they are associated with worse outcomes and suggest convergent evolutionary targeting of the cohesin gene.

bioRxiv · Sep 3, 2026 · PreprintCancer Biology

Altered chromatin accessibility mediated by somatic cohesin mutations amplifies FLI1-Menin output to promote leukemogenesis

Jane Jialu Xu, Viviana Scoca, Yi Chen, Yingqian Ada Zhan, Alexander Fisher, Eno-obong Udoh, Sebastian Fernando, Besmira Alija, John Pantazi, Varun S. Sudunagunta, Edna Stewart, Anabella Maria D. Galang, Michael Williams, Govind Bhagat, Claudia Gebhard, , Aaron D. Viny

This study shows that cohesin mutations alter chromatin accessibility, enhancing FLI1-Menin interaction and promoting leukemogenesis through therapeutic vulnerabilities.

bioRxiv · Apr 1, 2025 · PreprintCancer Biology