Randolph Scott Ashton

The paper develops a human microphysiological model of dorsal root ganglion-spinal cord dorsal horn circuitry that mimics opioid-induced effects through electrophysiological responses.

The paper introduces the RosetteArray platform for high-throughput screening of neurodevelopmental risk by culturing standardized neural rosettes from human pluripotent stem cells and analyzing them with AI.

This paper shows that CRISPRa activation of two endogenous regulatory elements can self-organize ESCs into embryo-like structures with spatial and molecular features similar to pre-gastrulation mouse embryos.

This study shows SYNGAP1, an autism risk gene, is expressed in human cortical progenitors and its dysfunction disrupts neurogenesis and cortical lamination.

The paper develops a modular differentiation system to generate diverse human hindbrain and spinal neurons and uses computational methods to identify region-specific transcriptomic patterns.