Lyndsay E.A. Young

This study uses cortical organoids to show that ALG13 loss-of-function causes glycosylation defects, neuronal maturation issues, and network hypoactivity in CDG.

This study identifies hyper-glycosylation as a driver of Alzheimer's disease through metabolic analysis and interventions, showing its impact on cognitive decline and mortality.

This study identifies APOE4-associated metabolic changes in brain and systemic metabolism, showing increased aerobic glycolysis and reduced oxidative metabolism in both mice and humans.

This study shows that cervical spinal cord injury in rats leads to acute lung injury and metabolic dysfunction, establishing a new animal model for studying this relationship.

The paper introduces Madi, a workflow combining MALDI-MSI and machine learning to analyze FFPE tissues, revealing metabolic patterns and pathological features in human tissues.