HAP40 functions as a proteostasis regulator by controlling huntingtin interactions and its release into the extracellular space
Eduardo Silva Ramos, Annett Boeddrich, Christian Haenig, Philipp Trepte, Orchid Ammar, Christopher Secker, Oliver Popp, Andranik Ivanov, Brandon A. Keith, Rachel J. Harding, Franziska Schindler, Tomáš Koudelka, Leonard Roth, Nadine Scharek, Martina Zenkner, , Erich E. Wanker
This study identifies HAP40 as a proteostasis regulator that controls HTT interactions and mHTT secretion, impacting cellular homeostasis and pathobiology.
bioRxiv · Apr 1, 2026 · PreprintCell Biology