The paper introduces NIL-TDS, a method for quantifying small RNA slicing activity, and demonstrates its application in detecting slicing events in plants and mammals.

bioRxiv · Sep 30, 2025 · PreprintMolecular Biology

Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

Jan Dreute, Julia Stengel, Jonas Becher, David R. van den Borre, Maximilian Pfisterer, Marek Bartkuhn, Vanessa M. Beutgen, Benardina Ndreshkjana, Ulrich Gärtner, Johannes Graumann, Michael B. Huck, Stephan Klatt, Chloe Liliana Leff, Henner F. Farin, Andrea Nist, , Michael Lienhard Schmitz

This study identifies synergistic metabolic inhibitors that selectively target ovarian and colorectal cancer cells by disrupting both glycolysis and oxidative phosphorylation.

Cell Death and Differentiation · Jun 23, 2025Peer-reviewedCancer Biology

The proximity-based protein interaction landscape of the transcription factor p65 NF-kappaB/RELA and its gene-regulatory logics

Lisa Leib, J. Unternaehrer Juli, Liane Jurida, Christin Mayr‐Buro, Jasmin Priester, Hendrik Weiser, Stefanie Wirth, Simon Hanel, Daniel Heylmann, Axel Weber, Michael Lienhard Schmitz, Argyris Papantonis, Marek Bartkuhn, Jochen Wilhelm, Uwe Linne, , Michael Kracht

The paper identifies >350 p65/RELA interactors and reveals gene regulatory networks controlled by RELA and its interactors in the IL-1 response.

EMBO Reports · Jan 3, 2025Peer-reviewedMolecular Biology

A common gene signature of the right ventricle in failing rat and human hearts

Liane Jurida, Sebastian Werner, Fabienne Knapp, Bernd Niemann, Ling Li, Dimitri Grün, Stefanie Wirth, Axel Weber, Knut Beuerlein, Christoph Liebetrau, Christoph B. Wiedenroth, Stefan Guth, Baktybek K. Kojonazarov, Leili Jafari, Norbert Weißmann, , Michael Kracht

The paper identifies a conserved gene signature associated with right ventricular failure in both rat and human hearts through transcriptomic analysis and validation.

Nature Cardiovascular Research · Jul 5, 2024Peer-reviewedGenomics