Uwe Linne

Discovery of a Cell-Permeable Gi-Signaling Inhibitor

This paper discovers NHAP, a fungal metabolite that selectively inhibits Gi-signaling, demonstrating functional blockade in cardiomyocytes without cytotoxicity.

PERK inhibition rewires translational and CMGC protein kinase networks into an antiviral state

The paper shows that inhibiting PERK rewires host kinase networks to create an antiviral state during coronavirus infection.

The proximity-based protein interaction landscape of the transcription factor p65 NF-kappaB/RELA and its gene-regulatory logics

The paper identifies >350 p65/RELA interactors and reveals gene regulatory networks controlled by RELA and its interactors in the IL-1 response.

Cyclase-associated protein 1 (CAP1) represses MRTF-SRF-dependent gene expression in the mouse cerebral cortex

This study identifies CAP1 as a repressor of MRTF-SRF signaling in mouse neurons through actin-dependent mechanisms and validates its role in gene regulation in the cerebral cortex.