Author

Chloe Liliana Leff

Justus-Liebig-Universität GießenORCID 0000-0002-9036-4099Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alfredo Cabrera‐OreficeiD· 1 shared Andrea NistiD· 1 shared Benardina NdreshkjanaiD· 1 shared Bruna de Gois MacedoiD· 1 shared Caio Loureiro SalgadoiD· 1 shared Carly R. StolliD· 1 shared David R. van den BorreiD· 1 shared Emily WhiteiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Alfredo Cabrera‐OreficeORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

Jan Dreute, Julia Stengel, Jonas Becher, David R. van den Borre, Maximilian Pfisterer, Marek Bartkuhn, Vanessa M. Beutgen, Benardina Ndreshkjana, Ulrich Gärtner, Johannes Graumann, Michael B. Huck, Stephan Klatt, Chloe Liliana Leff, Henner F. Farin, Andrea Nist, , Michael Lienhard Schmitz

This study identifies synergistic metabolic inhibitors that selectively target ovarian and colorectal cancer cells by disrupting both glycolysis and oxidative phosphorylation.

Cell Death and Differentiation · Jun 23, 2025Peer-reviewedCancer Biology

Sensing of extracellular ATP via P2RX7 drives lung tumor growth through regulatory T cell suppressive function

Igor Santiago-Carvalho, Ronaldo da Silva Francisco, Bruna de Gois Macedo, Caio Loureiro Salgado, Carly R. Stoll, Marcos Pinheiro Cione, Emily White, Tyler Johnston, Chloe Liliana Leff, Ildefonso Silva, Fabio Carvalho de Souza, Maria Regina D’Império Lima, Jessica Naomi Lancaster, Henrique Borges da Silva

This study identifies P2RX7 as a key regulator of Treg suppressive function in lung tumors, showing that targeting P2RX7 could improve lung cancer treatment by reducing Treg-mediated immune suppression.

bioRxiv · May 3, 2025 · PreprintImmunology