This paper develops a device-encapsulated MSC system for sustained secretome delivery to treat ischaemic heart injury, showing improved cardiac function and reduced remodelling in rats.

Stem Cell Research & Therapy · Dec 5, 2025Peer-reviewedPathology

Optimised proteomic analysis of insulin granules from MIN6 β-cells identifies Scamp3, a novel regulator of insulin secretion and content

Nicholas Norris, Belinda Yau, Carlo Famularo, Hayley Webster, Thomas Loudovaris, Helen E. Thomas, Mark Larance, Alistair McNair Senior, Melkam Alamerew Kebede

This study identifies 211 proteins associated with insulin secretory granules in MIN6 β-cells, including SCAMP3, which regulates insulin storage and secretion.

Diabetes · Sep 25, 2024Peer-reviewedCell Biology

A pro-endocrine pancreatic transcriptional program established during development is retained in human gallbladder epithelial cells

Mugdha V. Joglekar, Subhshri Sahu, Wilson K. M. Wong, Sarang N. Satoor, Charlotte X. Dong, Ryan J. Farr, Michael D. Williams, Prapti Pandya, Gaurang Jhala, Sundy N.Y. Yang, Yi Vee Chew, Nicola A. Hetherington, Dhan Thiruchevlam, Mitnala Sasikala, Guduru Venkat Rao, , Anandwardhan A. Hardikar

The paper shows human gallbladder epithelial cells retain a pro-endocrine pancreatic transcriptional program, enabling insulin production and immune protection in type 1 diabetes.

bioRxiv · Mar 2, 2021 · PreprintDevelopmental Biology