Transient efferocytosis-induced activation of IKKβ reprograms macrophages to promote tissue resolution
David Ngai, Saheli Chowdhury, Santosh Reddy Sukka, George Kuriakose, Brian T Havens, Mustafa Yalçınkaya, Jeremy M. Frey, Heather Doviak, Jennifer W. Bradford, Bernhard Dorweiler, Hanna Winter, Lars Mäegdefessel, Kenneth Walsh, Joshua P. Thaler, Alan R. Tall, Ira A. Tabas
This study identifies IKKβ activation as a transient upstream signal triggered by efferocytosis that promotes tissue resolution through multiple downstream pathways.
Nature Communications · Oct 26, 2026Peer-reviewedImmunology