Author

Merit Cudkowicz

Massachusetts General HospitalORCID 0000-0002-7075-1681Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Bradley T. HymaniD· 2 shared Nazem AtassiiD· 2 shared Aaron Ofori-KuraguiD· 1 shared Abigail A. Obeng-MarnuiD· 1 shared Adam GodzikiD· 1 shared Adriano ChiòiD· 1 shared Adrienne O’DonnelliD· 1 shared Agnieszka Kitlas GolińskaiD· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersNeuroscience

Bradley T. HymanORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targeting tau mitigates mitochondrial fragmentation and oxidative stress in amyotrophic lateral sclerosis

Tiziana Petrozziello, Evan A. Bordt, Alexandra N. Mills, Spencer E. Kim, Ellen Sapp, Benjamin A. Devlin, Abigail A. Obeng-Marnu, Sali M.K. Farhan, Ana Claudia Silva Amaral, Simon Dujardin, Patrick M. Dooley, Christopher M. Henstridge, Derek H. Oakley, Andreas Neueder, Bradley T. Hyman, , Ghazaleh Sadri‐Vakili

This study shows that reducing tau with a degrader prevents mitochondrial fragmentation and oxidative stress in ALS models.

Molecular Neurobiology · Nov 10, 2021Peer-reviewedNeuroscience

Partitioning the genetic architecture of amyotrophic lateral sclerosis

Iris Broce, Chun Chieh Fan, Nicholas T. Olney, Catherine Lomen‐Hoerth, Steven M. Finkbeiner, Nazem Atassi, Merit Cudkowicz, Sabrina Paganoni, Jennifer S. Yokoyama, Aimee W. Kao, William P. Dillon, Christine M. Glastonbury, Christopher Paul Hess, Wouter van Rheenen, Jan Herman Veldink, , Rahul S. Desikan

This study identifies genetic variants and networks associated with ALS using GWAS data, revealing novel loci and functional sub-networks linked to disease.

bioRxiv · Feb 24, 2019 · PreprintGenetics

Stratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach

Robert Kueffner, Neta Zach, Maya Bronfeld, Raquel Norel, Nazem Atassi, Venkatachalapathy S. K. Balagurusamy, Barbara Di Camillo, Adriano Chiò, Merit Cudkowicz, Donna Eng Dillenberger, Javier Garcı́a-Garcı́a, Orla M. Hardiman, Bruce Hoff, Joshua Knight, Melanie L. Leitner, , Shihua Zhang

This study uses a crowdsourcing approach to stratify ALS patients, identifying four distinct clusters with unique predictors and improving outcome prediction.

Scientific Reports · Jan 24, 2019Peer-reviewedBioinformatics

Genome-encoded Cytoplasmic Double-Stranded RNAs, Found in C9ORF72 ALS-FTD Brain, Provoke Propagated Neuronal Death

Steven Rodriguez, Benjamin R. Schrank, Aslı Şahin, Hawra J. Al Lawati, Isabel M. Costantino, Eric G. Benz, Darian Fard, Alefiya Dhilla Albers, Luxiang Cao, Alexis C. Gomez, Elena Ratti, Merit Cudkowicz, Matthew P. Frosch, Michael E. Talkowski, Peter Karl Sorger, , Mark W. Albers

The paper shows that cytoplasmic double-stranded RNA (cdsRNA) from C9ORF72 expansions in ALS-FTD brains triggers IFN-I signaling and neuronal death through a viral-mimetic mechanism.

bioRxiv · Jan 19, 2018 · PreprintNeuroscience