Author

Marie K. Holt

Florida State UniversityORCID 0000-0002-7104-206XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3

Frequent Co-Authors

Daniel I. BrierleyiD· 2 shared Fiona Mary GribbleiD· 2 shared Frank M. ReimanniD· 2 shared Linda RinamaniD· 2 shared Stefan TrappiD· 2 shared Alan de AraujoiD· 1 shared Annette D. de KloetiD· 1 shared Arashdeep SinghiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersNeuroscience

Daniel I. BrierleyORCID

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3 papers

Recent·Most cited

Brainstem GLP-1 neurons modulate physiological satiation and drive sustained weight loss in obese mice

Wanqing Jiang, Cecilia Skoug, Ian Rodrigues, Ernesto Ciabatti, Fiona Mary Gribble, Frank M. Reimann, Daniel I. Brierley, Marie K. Holt, Stefan Trapp

This study shows that chronic activation of GLP-1 neurons in the brainstem reduces food intake and causes sustained weight loss in obese mice.

Molecular Metabolism · Mar 4, 2026Peer-reviewedNeuroscience

Modulation of stress-related behaviour by hypothalamic engagement of preproglucagon neurons in the nucleus of the solitary tract

Marie K. Holt, Natalia Valderrama, María José Polanco, Linda Rinaman

This study identifies a hypothalamic-brainstem pathway involving PPG neurons in stress-induced anxiety-like behaviours and hypophagia, with sex-dependent effects.

bioRxiv · Feb 4, 2022 · PreprintNeuroscience

Central and peripheral GLP-1 systems independently and additively suppress eating

Daniel I. Brierley, Marie K. Holt, Arashdeep Singh, Alan de Araujo, Molly J. McDougle, Macarena Vergara, Majd H. Afaghani, Shin Jae Lee, Karen A. Scott, Calyn B. Maske, Wolfgang Langhans, Eric G. Krause, Annette D. de Kloet, Fiona Mary Gribble, Frank M. Reimann, , Stefan Trapp

The paper shows that central and peripheral GLP-1 systems independently suppress eating, and PPGNTS neuron activation addsitively enhances this effect with GLP-1 agonists.

Nature Metabolism · Feb 15, 2021Peer-reviewedNeuroscience