Efficacy of glucocorticoid modulator PT150 as a weight loss strategy
Victoria Marie Glass, Molly J. McDougle, Whitnei Smith, Parker S. Dhillon, Lanah Ha, José Henrique Ledo, Christopher D. Verrico, Estefania P. Azevedo
This study evaluates PT150, a GR antagonist, as a weight loss strategy in combination with semaglutide in diet-induced obese mice, showing improved weight reduction and setpoint maintenance.
bioRxiv · Apr 7, 2026 · PreprintPhysiology