Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase
Zhuoyao Chen, Jinwei Zhang, Adrián Rafael Murillo‐de‐Ozores, María Castañeda‐Bueno, Francesca D’Amico, Raphael Heilig, Charlotte E. Manning, F.J. Sorrell, Vincenzo D’Angiolella, Román Fischer, Monique P. C. Mulder, Gerardo Gamba, Dario R. Alessi, Alex N. Bullock
This paper determines the crystal structure of KLHL3 in complex with a WNK3 peptide, revealing structural features and phosphorylation-dependent regulation of WNK3 binding.
Biochemical Journal · Feb 18, 2022Peer-reviewedMolecular Biology