Maria‐Eirini Pandelia

Promiscuous Metal Site in Hepatitis B Virus X Protein Binds anFe-S Cluster

This study identifies Fe-S cluster ligands in HBx, showing it binds both Fe-S and Zn, with implications for HBV replication and drug targeting.

Polyamines buffer labile iron to suppress ferroptosis

This study shows polyamines buffer labile iron to suppress ferroptosis by linking polyamine metabolism to iron homeostasis through a genome-wide CRISPR screen and fluorescent reporter.

Amino Acids in the RSSY Motif of Lipoyl Synthase Control Substrate Binding and Reactivity

This paper investigates the role of amino acids in the RSSY motif of lipoyl synthase, showing that Arg306 and Ser308 are critical for substrate binding and catalytic activity, with specific substitutions affecting product formation and cluster stability.

Transition metal activation reframes SAMHD1 regulation

This study identifies transition metals, particularly iron, as essential for SAMHD1 function, revealing their role in catalysis and allosteric regulation.

Discovery of a cluster in the PRRSV Nsp1α leader protease reveals host-virus interplay in its downstream functions

The paper identifies a [4Fe-4S] cluster in PRRSV Nsp1α leader protease, showing its role in modulating protease activity and host-virus interactions.

Feedback regulation of iron-sulfur cluster biogenesis

The paper identifies a feedback mechanism in Mycobacterium tuberculosis where [2Fe-2S] clusters inhibit sulfide supply by regulating the SufS/SufU complex.