Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model
Livia Piatti, Alina Batzilla, Fumio Nakaki, Hannah Fleckenstein, François Korbmacher, Rory K. M. Long, Daniel Schraivogel, John A. Hawkins, Tais Romero-Uruñuela, Borja López-Gutiérrez, Sílvia Sanz, Yannick Schwab, Lars Michael Steinmetz, James A. Sharpe, Maria Bernabeu
This study shows that Plasmodium falciparum egress products disrupt BBB endothelial junctions and activate JAK-STAT signaling, leading to increased permeability and suggesting therapeutic targets.
Nature Communications · Aug 6, 2025Peer-reviewedMicrobiology