Nucleosomal Asymmetry Shapes Histone Mark Binding and Promotes Poising at Bivalent Domains
Elana Bryan, Devisree Valsakumar, Nwamaka J. Idigo, Marie Warburton, Kimberly M. Webb, Katy A. McLaughlin, Christos Spanos, Simone Lenci, Viktoria Major, Christina Ambrosi, Simon Andrews, Tuncay Baubec, Juri Rappsilber, Philipp Voigt
The paper shows that asymmetric bivalent nucleosomes at developmental gene promoters promote a poised state by recruiting repressive H3K27me3 binders and specific chromatin proteins like KAT6B, which is critical for ESC differentiation.
Molecular Cell · Dec 27, 2024Peer-reviewedMolecular Biology