Author

Viktoria Major

Wellcome Centre for Cell Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:ChIP-seq· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Philipp VoigtiD· 3 shared Elana BryaniD· 2 shared Kimberly M. WebbiD· 2 shared Andrea BaconiD· 1 shared Andrea CorsinottiiD· 1 shared Benjamin BerubeiD· 1 shared Chantal LeBlanciD· 1 shared Chengrui An· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersMolecular Biology

Philipp VoigtORCID

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Author profile →

4 papers

Recent·Most cited

Watch-breaker: establishment of a microwell array-based miniaturized thymic organoid model suitable for high throughput applications.

Viktoria Major, Sam Palmer, Paul Rouse, Jan Morys, Timothy Henderson, Tania Hübscher, Joanna Sweetman, Andrea Bacon, Chengrui An, Guiyun Qiu, Yu Wang, Andrea Corsinotti, Justyna Cholewa-Waclaw, Stephen Jonathan Chapman, Matthias P. Lütolf, , Clare C. Blackburn

The paper introduces a microwell array-based thymic organoid model that supports T-cell development and is suitable for high-throughput analysis.

Cell Reports · Apr 15, 2025Peer-reviewedImmunology

Nucleosomal Asymmetry Shapes Histone Mark Binding and Promotes Poising at Bivalent Domains

Elana Bryan, Devisree Valsakumar, Nwamaka J. Idigo, Marie Warburton, Kimberly M. Webb, Katy A. McLaughlin, Christos Spanos, Simone Lenci, Viktoria Major, Christina Ambrosi, Simon Andrews, Tuncay Baubec, Juri Rappsilber, Philipp Voigt

The paper shows that asymmetric bivalent nucleosomes at developmental gene promoters promote a poised state by recruiting repressive H3K27me3 binders and specific chromatin proteins like KAT6B, which is critical for ESC differentiation.

Molecular Cell · Dec 27, 2024Peer-reviewedMolecular Biology

Chromatin remodeling of histone H3 variants underlies epigenetic inheritance of DNA methylation

Seung Cho Lee, Dexter W. Adams, Jonathan J. Ipsaro, Jonathan Cahn, Jason S. Lynn, Hyun Soo Kim, Benjamin Berube, Viktoria Major, Joseph P. Calarco, Chantal LeBlanc, Sonali Bhattacharjee, Umamaheswari Ramu, Daniel Grimanelli, Yannick Jacob, Philipp Voigt, , Robert A. Martienssen

The paper shows that DDM1 remodels histone H3 variants to facilitate epigenetic inheritance of DNA methylation by interacting with specific histone modifications and variants.

Cell · Aug 28, 2023Peer-reviewedMolecular Biology

The TAZ2 domain of CBP/p300 directs acetylation towards H3K27 within chromatin

Thomas W. Sheahan, Viktoria Major, Kimberly M. Webb, Elana Bryan, Philipp Voigt

This study identifies the TAZ2 domain of CBP/p300 as essential for directing acetylation towards H3K27 in chromatin, enhancing specificity and gene expression regulation.

bioRxiv · Jul 21, 2020 · PreprintMolecular Biology