Author

Vitaly Epshtein

New York University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 3 Assay:ChIP-seq· 2 Organism:E. coli· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Evgeny NudleriD· 4 shared Ilya ShamovskyiD· 4 shared Alexey A. GavriloviD· 2 shared Artem B. IsaeviD· 2 shared Konstantin SeverinoviD· 2 shared Aleksandr A. ShenfeldiD· 1 shared Alexandr Andriianov· 1 shared Alina Demkina· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersMolecular Biology

Evgeny NudlerORCID

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4 papers

Recent·Most cited

H-NS silences antiviral immunity through 3D chromatin compaction

Timofey Khvostikov, Polina Iarema, Alexey A. Gavrilov, Ilya Shamovsky, Vitaly Epshtein, Alexandr Andriianov, Polina Baikuzina, Elena Ilyasovna Shagimardanova, Dmitry Senko, Thomas Keith Wood, Konstantin Severinov, Evgeny Nudler, Artem B. Isaev

This study shows H-NS silences bacterial antiviral immunity by compacting chromatin, and its deletion enhances phage defense in E. coli.

bioRxiv · Sep 11, 2026 · PreprintMolecular Biology

OLD sentinel: an abortive tRNase surveys phage replication and DNA defects in RecBCD-compromised cells

Anton Derzhaev, Jing Zhang, Alexey A. Gavrilov, Svetlana Belukhina, Aleksandr A. Shenfeld, Florence Depardieu, Baptiste Saudemont, Ilya Shamovsky, Vitaly Epshtein, Alina Demkina, Huaile Song, Olga Yu. Burenina, Mikhail A. Skutel, Maria A. Tikhomirova, Vadim Molodtsov, , Artem B. Isaev

This paper characterizes OLD, an abortive immunity protein, revealing its structure and activation mechanism in response to phage replication and DNA defects in RecBCD-compromised cells.

bioRxiv · Jul 10, 2026 · PreprintMolecular Biology

Persistence of backtracking by human RNA polymerase II

Kevin B. Yang, Aviram Rasouly, Vitaly Epshtein, Criseyda Martinez, Thao Duy Nguyen, Ilya Shamovsky, Evgeny Nudler

This study identifies persistent RNA polymerase II backtracking in human cells and shows its enrichment in genes involved in translation, replication, and development.

Molecular Cell · Feb 9, 2024Peer-reviewedMolecular Biology

General Transcription Factor from E. coli with a Distinct Mechanism of Action

Nikita Vasilyev, Mengjie Liu, Vitaly Epshtein, Ilya Shamovsky, Evgeny Nudler

The paper identifies CedA as a general transcription factor in E. coli that stabilizes an open-promoter complex without contacting DNA and modulates gene expression under stress conditions.

bioRxiv · Sep 17, 2023 · PreprintMolecular Biology