Flavia Marzetta

Modelling interpretable patient-level representationsfrom structured and simple multimodal data

The paper introduces FACTMx, a variational framework that jointly models structured and simple patient-level data to learn interpretable representations, showing improved performance in simulations and applications to cancer and cardiovascular cohorts.

Identification of a unique transcriptomic signature associated with islet amyloidosis

This study identifies transcriptomic changes in islet amyloidosis using RNA sequencing and finds a gene co-expression module linked to the condition.

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes

This study uses multi-omics analysis of pancreatic islet donors to show heterogeneous beta cell changes associated with type 2 diabetes progression.

Three-dimensional chromatin interactions remain stable upon CAG/CTG repeat expansion

This study investigates whether CAG/CTG repeat expansion alters chromatin folding using 4C sequencing and finds that chromatin contacts remain stable despite repeat expansion.

The KZFP/KAP1 system controls transposable elements-embedded regulatory sequences in adult T cells

The paper shows that the KZFP/KAP1 system dynamically regulates TEeRS in adult human T cells, affecting gene expression and chromatin states.