Author

Matthew J. Martin

AstraZeneca (United Kingdom)ORCID 0000-0002-8948-961XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:imaging· 1

Frequent Co-Authors

A. J. Narvaez· 1 shared A. M. I. Le MaroisiD· 1 shared Charles SwantoniD· 1 shared Christopher W. DunsbyiD· 1 shared Deborah R. CaswelliD· 1 shared Erik A. SahaiiD· 1 shared Fabian FröhlichiD· 1 shared Giuditta IlluzziiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. J. Narvaez

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 21, 2026

The EGFR inhibitor osimertinib promotes a dynamic Drug Tolerant Persister state marked by replication defects and genome instability

Kieron May, Giuditta Illuzzi, Matthew J. Martin, Jonathan M. Houseley

This study shows that osimertinib treatment leads to a Drug Tolerant Persister state with replication defects, genome instability, and hypersensitivity to DNA repair inhibitors.

DOI 10.64898/2026.06.19.733326

humanDNA methylation

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Cancer BiologybioRxivPreprintMay 14, 2024

Imaging of MAP kinase dynamics reveals endocytic regulation of pulsatile signalling and network re-wiring in response to targeted therapy in EGFR-mutant non-small cell lung cancer

A. M. I. Le Marois, Sasha Bailey, Steven Hooper…·Erik A. Sahai

The paper uses single-cell imaging to show that drug-tolerant cells in EGFR-mutant lung cancer rewired ERK signaling through endocytic pathways and adhesion complexes, driven by YAP and PTPRS.

3 citations

humanimaging

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