Miguel Ángel Chiurillo

This study identifies two cAMP microdomains in Trypanosoma cruzi, showing their distinct roles in parasite survival and infection.

This study identifies TcRDK2 as a NEK kinase essential for kinetoplast segregation, metacyclogenesis, and host-cell infection in T. cruzi, highlighting it as a potential therapeutic target for Chagas disease.

This study shows that reducing IP6K levels in T. cruzi impairs key life-cycle transitions and intracellular development in human cardiomyocytes, suggesting IP6K as a potential drug target for Chagas disease.

This study identifies TcCARP3 as a regulator of cAMP signaling in Trypanosoma cruzi, essential for osmoregulation, host cell invasion, and vector colonization.