Ferroptosis regulates hemolysis in stored murine and human red blood cells
Angelo D’Alessandro, Gregory R. Keele, Ariel M. Hay, Travis G. Nemkov, Eric J. Earley, Daniel Stephenson, Matthew J. Vincent, Xutao Deng, Mars Stone, Monika Dzieciątkowska, Kirk Charles Hansen, Steven H Kleinman, Steven L. Spitalnik, Nareg H. Roubinian, Philip J. Norris, , James C. Zimring
This study identifies Steap3 as a regulator of ferroptosis-like lipid peroxidation in stored RBCs, linking genetic variants to hemolysis in mice and human blood donors.
Blood · Nov 14, 2024Peer-reviewedBiochemistry