Author

Travis E. Law

Broad InstituteORCID 0000-0002-7399-3299Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alison BrackiD· 1 shared Andrew EarliD· 1 shared Aviv RegeviD· 1 shared Bing ZhangiD· 1 shared Caleb A. LareauiD· 1 shared Faiza BatooliD· 1 shared Gareth ChapmaniD· 1 shared Haley JetteriD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenomics

Alison BrackORCID

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Author profile →

2 papers

Recent·Most cited

Tatton-Brown-Rahman-Syndrome-associated DNMT3A mutations de-repress cortical interneuron differentiation to disrupt neuronal network function

Gareth Chapman, Julianna J. Determan, John R. Edwards, Faiza Batool, James E. Huettner, Ramachandran Prakasam, Sydney R. Crump, Yasmin Razia, Sofia Malik, Travis E. Law, Haley Jetter, Harrison W. Gabel, Kristen L. Kroll

This study shows that DNMT3A mutations in TBRS disrupt cortical interneuron differentiation, leading to neuronal network dysfunction and contributing to intellectual disability and autism.

bioRxiv · Jun 24, 2025 · PreprintNeuroscience

Chromatin potential identified by shared single cell profiling of RNA and chromatin

Sai Ma, Bing Zhang, Lindsay M. LaFave, Andrew Earl, Zachary Chiang, Yan Hu, Jiarui Ding, Alison Brack, Vinay K. Kartha, Tristan Tay, Travis E. Law, Caleb A. Lareau, Ya‐Chieh Hsu, Aviv Regev, Jason Daniel Buenrostro

The paper introduces SHARE-seq, a method to profile RNA and chromatin in single cells, and identifies DORCs that predict lineage commitment by chromatin accessibility changes.

Cell · Oct 23, 2020Peer-reviewedGenomics