The paper uses patient-derived explants to study BiTE-driven T cell responses in tumors, identifying the COX/PGE2 axis as a barrier to immune activation and showing COX inhibition enhances anti-tumor effects.

bioRxiv · Mar 30, 2026 · PreprintSystems Biology

Key determinants of T cell epitope recognition revealed by TCR specificity profiles

Yan Liu, Giancarlo Croce, Daniel M. Tadros, Dana Léa Moreno, Alexandra Michel, Anne‐Christine Thierry, Raphaël Genolet, Marta A. S. Perez, Rachid Lani, Philippe Guillaume, Michaël Hebeisen, Matei Teleman, Kelvin Lau, Amédé Larabi, Julien Racle, , David Gfeller

The paper introduces TCR specificity profiles to identify key determinants of TCR-epitope recognition and shows their ability to predict cross-reactivity and interpret machine learning models.

bioRxiv · Nov 17, 2025 · PreprintImmunology

Phage display enables machine learning discovery of cancer antigen specific TCRs

Giancarlo Croce, Rachid Lani, Delphine Tardivon, Sara Bobisse, Mariastella de Tiani, Maiia E. Bragina, Marta A. S. Perez, Justine Michaux, Hui Song Pak, Alexandra Michel, Talita Gehret, Julien Schmidt, Philippe Guillame, Michal Bassani‐Sternberg, Vincent Zoete, , David Gfeller

The paper uses phage display and machine learning to discover TCRs specific to cancer antigens, identifying functional TCRs from large repertoires.

Science Advances · Jun 11, 2025Peer-reviewedBioinformatics