Julie B. Sneddon

This study maps the extracellular matrix gene expression landscape in human pancreas using spatial transcriptomics, revealing pericytes as the main source of vascular basement membrane components and identifying disease-related changes in type 2 diabetes.

This study develops human pancreatic organoids from pluripotent stem cells that recapitulate pancreatic development, including ductal network formation and endocrine cell generation.

This study uses single-nucleus ATAC-sequencing to analyze chromatin accessibility and RNA expression in developing mouse pancreas, identifying gene regulatory programs and transcription factors involved in cell fate determination.

This study shows Rab11 is essential for pancreas development, lumen formation, and endocrine mass by regulating epithelial morphogenesis and vesicle trafficking.

This study maps human fetal pancreatic development using scRNA-Seq and snATAC-Seq, identifying novel cell types and regulatory mechanisms, and highlights gene FEV's role in endocrine differentiation.

The paper constructs a single-cell RNA-seq atlas of the adult Drosophila ovary and identifies a new form of cellular plasticity in response to starvation.

This study maps mouse and human cochlea development using single-cell RNA-sequencing and a new clustering algorithm, identifying new cell types and gene associations related to hearing loss.