Martin Cohen‐Gonsaud

CF2H: a Cell-Free Two-Hybrid platform for rapid protein binder screening

CF2H is a cell-free two-hybrid platform that rapidly detects high-affinity protein-protein interactions without cloning or purification.

A scalable architecture for tuning multistate differentiation ratios in synthetic microbial consortia

This paper introduces a synthetic biology framework that enables tunable differentiation ratios in microbial consortia, validated in a mouse tumor model.

Split minireporters facilitate monitoring of gene expression and peptide production in linear cell-free transcription-translation systems

This paper introduces minireporters for monitoring gene expression and peptide production in cell-free systems, reducing DNA length and synthesis costs while maintaining reliable output.

Cryo-EM structure of the transcription termination factor Rho from Mycobacterium tuberculosis reveals mechanism of resistance to bicyclomycin

The paper determines the cryo-EM structure of M. tuberculosis Rho, explaining its resistance to bicyclomycin and low enzymatic activity.

Differentially optimized cell-free buffer enables robust expression from unprotected linear DNA in exonuclease-deficient extracts

This paper develops exonuclease-deficient cell-free extracts and optimized buffers to enable robust expression from unprotected linear DNA without additional protection strategies.

The study of the determinants controlling Arpp19 phosphatase-inhibitory activity reveals a new Arpp19/PP2A-B55 feedback loop

This study identifies molecular determinants controlling Arpp19 phosphatase-inhibitory activity and reveals a feedback loop between two phosphorylation sites.

A synthetic receptor platform enables rapid and portable monitoring of liver dysfunction via engineered bacteria.

This paper introduces a synthetic receptor platform for detecting liver dysfunction biomarkers using engineered bacteria, achieving sensitive and portable diagnostics.