Marco Mariotti

Regulatory landscape of widespread stop codon readthrough in Drosophila

The paper identifies 1,400 stop codon readthrough genes in Drosophila, reveals sequence features associated with programmed readthrough, and shows conserved cis-elements functional in mammalian cells.

Tracing the vertebrate selenoproteome evolution reveals expansions in ray-finned fishes and convergent depletions in tetrapods

Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases

The paper identifies widespread misannotations of vertebrate selenoprotein genes in public databases and introduces an improved homology-based tool for accurate prediction.

Pyranges v1: a Python framework for ultrafast sequence interval operations

Pyranges v1 provides a Python framework for efficient sequence interval operations, offering speed and functionality improvements over existing tools like BEDTools.

Deterioration of the human transcriptome with age due to increasing intron retention and spurious splicing

The paper shows that aging leads to increased intron retention and spurious splicing, causing transcriptome deterioration across multiple human tissues.

In vivo reprogramming and epigenetic rejuvenation of adult cardiomyocytes ameliorate heart failure in mice

This study shows that cyclic OKSM expression rejuvenates adult cardiomyocytes in mice with heart failure, improving systolic function without dedifferentiation.

The tuatara genome: insights into vertebrate evolutionfrom the sole survivor of an ancient reptilian order

The paper presents the tuatara genome, highlighting its evolutionary significance and unique features compared to other vertebrates.

Use of selenocysteine, the 21st amino acid, in the fungal kingdom

The paper identifies selenoproteins in five fungal species, showing the presence of Sec utilization machinery and SECIS elements, and documents the loss of Sec in various fungal lineages.

Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization

The paper traces the evolutionary history of selenophosphate synthetase (SPS) genes, showing how they duplicated and subfunctionalized to acquire distinct roles in metazoans.