Author

Christina James

Friedrich-Alexander-Universität Erlangen-NürnbergORCID 0000-0002-7443-929XUnclaimed ORCID profile · follow to get notified of new preprints

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Christina James2 papers · University of Georgia

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Anne HartebrodtiD· 1 shared Arne GessneriD· 1 shared Beate WinneriD· 1 shared Bruno GhirottoiD· 1 shared Claudia GüntheriD· 1 shared David B. BlumenthaliD· 1 shared Elizaveta M. GerasimovaiD· 1 shared Fabian Joachim TheisiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Anne HartebrodtORCID

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1 paper

Recent·Most cited

TNF-α disrupts the malate-aspartate shuttle, driving metabolic rewiring in iPSC-derived enteric neural lineages from Parkinson's Disease patients

Bruno Ghirotto, Luís Eduardo Gonçalves, Vivien Ruder, Christina James, Elizaveta M. Gerasimova, Tania Rizo, Holger Wend, Michaela Farrell, Juan Gerez, Natalia Cecilia Prymaczok, Merel Kuijs, Maiia Shulman, Anne Hartebrodt, Iryna Prots, Arne Gessner, , Beate Winner

This study shows TNF-α disrupts the malate-aspartate shuttle in iPSC-derived enteric neural cells from PD patients, causing metabolic shifts and mitochondrial dysfunction, which can be reversed by targeting glutamate metabolism.

Nature Communications · Apr 1, 2026Peer-reviewedNeuroscience