Author

Michaela Farrell

Friedrich-Alexander-Universität Erlangen-Nürnberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Beate WinneriD· 3 shared Jürgen WinkleriD· 3 shared Claudia GüntheriD· 2 shared Fabian Joachim TheisiD· 2 shared Martin RegensburgeriD· 2 shared Pooja GuptaiD· 2 shared André ReisiD· 1 shared Anita M. RauchiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersNeuroscience

Beate WinnerORCID

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Author profile →

3 papers

Recent·Most cited

TNF-α disrupts the malate-aspartate shuttle, driving metabolic rewiring in iPSC-derived enteric neural lineages from Parkinson's Disease patients

Bruno Ghirotto, Luís Eduardo Gonçalves, Vivien Ruder, Christina James, Elizaveta M. Gerasimova, Tania Rizo, Holger Wend, Michaela Farrell, Juan Gerez, Natalia Cecilia Prymaczok, Merel Kuijs, Maiia Shulman, Anne Hartebrodt, Iryna Prots, Arne Gessner, , Beate Winner

This study shows TNF-α disrupts the malate-aspartate shuttle in iPSC-derived enteric neural cells from PD patients, causing metabolic shifts and mitochondrial dysfunction, which can be reversed by targeting glutamate metabolism.

Nature Communications · Apr 1, 2026Peer-reviewedNeuroscience

Deciphering Brain Organoids Heterogeneity by Identifying Key Quality Determinants

Daniel V. Kachkin, Naime Zagha, Tom Boerstler, Federica Furlanetto, Negar Nayebzade, Luke Zappia, Michelle Boisvert, Michaela Farrell, Sonja Ploetz, Martin Regensburger, Claudia Günther, Jürgen Winkler, Pooja Gupta, Fabian Joachim Theis, Marisa Karow, , Florian Krach

The paper identifies the Feret diameter as a reliable quality marker for brain organoids and shows mesenchymal cells negatively impact organoid formation.

bioRxiv · Jan 13, 2025 · PreprintNeuroscience

Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium

Bernt Popp, Mandy Krumbiegel, Janina Grosch, Annika Sommer, Steffen Uebe, Zacharias Kohl, Sonja Plötz, Michaela Farrell, Udo Trautmann, Cornelia S. Kraus, Arif Bülent Ekici, Reza Asadollahi, Martin Regensburger, Katharina Günther, Anita M. Rauch, , André Reis

The paper analyzes genetic integrity in iPSCs from the ForIPS consortium, identifying somatic variants and highlighting the need for individual clone evaluation.

Scientific Reports · Nov 15, 2018Peer-reviewedGenomics