Anoctamin-2-specific T Cells Link Epstein-Barr Virus to Multiple Sclerosis
Olivia G. Thomas, Urszula Rykaczewska, Marina Galesic, Rianne T. M. van der Burgt, Nils Hallen, Filippo Ferro, Mattias Bronge, Zoe Marti, Yue Li, Alexandra Hill Rique, Jianing Lin, Aleksa Krstic, Alicja Gromadzka, Andras Levente Szonder, Chiara Sorini, , Tomas P Olsson
CD4+ T cells cross-reactive between Epstein-Barr virus EBNA1 and the central nervous system channel anoctamin-2 (ANO2) are elevated in multiple sclerosis and exacerbate experimental autoimmune encephalomyelitis in mice.
Cell · Jan 1, 2026Peer-reviewedImmunology✦ In-depth digest