Per Uhlén

This study shows that cells decode calcium oscillation frequency through a multi-kinase network that regulates transcription via NF-κB and MYC.

This study shows that disrupting microglial TGF-β signaling causes region-specific demyelination in the spinal cord, with severity varying by age and sex.

CD4+ T cells cross-reactive between Epstein-Barr virus EBNA1 and the central nervous system channel anoctamin-2 (ANO2) are elevated in multiple sclerosis and exacerbate experimental autoimmune encephalomyelitis in mice.

This study develops a neoantigen-microbead platform for personalized T cell cancer vaccination and shows it effectively inhibits tumor growth in a mouse model.

The paper develops a multi-omics guided differentiation protocol to generate PD-vulnerable midbrain dopaminergic neurons, showing improved yield and functional recovery in mice.

This study shows that glioma-induced DNMT3A reduction in microglia leads to DNA demethylation and an anti-tumoral phenotype, suggesting DNMT3A as a therapeutic target for glioblastoma.

The paper develops TRIC-DISCO, a pipeline for whole-brain 3D RNA imaging in adult mice, enabling single-cell resolution of transcriptional signatures and markers without strict RNase-free conditions.

Spatial tri-omic sequencing (DBiT ARP-seq and DBiT CTRP-seq) and CODEX imaging map chromatin, RNA, and protein dynamics across mammalian brain development and lysolecithin-induced neuroinflammation.

The paper analyzes Ca2+ signaling transcriptomes in adult mouse and developing human brains, revealing lineage-specific gene regulation and functional differences in radial glia and neuronal progenitors.

The paper uses light-sheet fluorescence microscopy to visualize and analyze the complete vasculature of mouse eyes across development and disease.

This study identifies Arg1+ microglia as a distinct subtype in female mice, showing their role in cognitive function through dendritic spine maturation and behavior.