Yue Li

This study shows that disrupting microglial TGF-β signaling causes region-specific demyelination in the spinal cord, with severity varying by age and sex.

CD4+ T cells cross-reactive between Epstein-Barr virus EBNA1 and the central nervous system channel anoctamin-2 (ANO2) are elevated in multiple sclerosis and exacerbate experimental autoimmune encephalomyelitis in mice.

This study develops a neoantigen-microbead platform for personalized T cell cancer vaccination and shows it effectively inhibits tumor growth in a mouse model.

This study shows that glioma-induced DNMT3A reduction in microglia leads to DNA demethylation and an anti-tumoral phenotype, suggesting DNMT3A as a therapeutic target for glioblastoma.

The paper develops TRIC-DISCO, a pipeline for whole-brain 3D RNA imaging in adult mice, enabling single-cell resolution of transcriptional signatures and markers without strict RNase-free conditions.