CD4+ T cells cross-reactive between Epstein-Barr virus EBNA1 and the central nervous system channel anoctamin-2 (ANO2) are elevated in multiple sclerosis and exacerbate experimental autoimmune encephalomyelitis in mice.

Cell · Jan 1, 2026Peer-reviewedImmunology✦ In-depth digest

A neoantigen-microbead platform for personalized T cell cancer vaccination

Long Jiang, Birce Akpinar, Yue Li, Maryam Sanaee, Nathaniel A. Sanjaya, Karen Schmidt, Alejandro Fernandez-Woodbridge, Ola B. Nilsson, Luigi Notari, Csaba Kindler, Ingo Rimke, Olivia G. Thomas, Shigeaki Kanatani, Per Uhlén, Jerker Widengren, , Hans Grönlund

This study develops a neoantigen-microbead platform for personalized T cell cancer vaccination and shows it effectively inhibits tumor growth in a mouse model.

bioRxiv · Nov 21, 2025 · PreprintCancer Biology

Human placental stem cells induce a novel multiple myeloid cell-driven immunosuppressive program that ameliorates proinflammatory CNS pathology

Heela Sarlus, Yuxi Guo, Stefan Bencina, Keying Zhu, Vijay Joshua, Giulia Adriana Virgilio, Yufei Cheng, Jianing Lin, Jin-Hong Min, Irene Benito‐Cuesta, Valerie Suerth, Paula Trigo-Alonso, Olivia G. Thomas, Urszula Rykaczewska, André Ortlieb Guerreiro Cacais, , Robert Adam Harris

This study shows that human amniotic epithelial cells reduce CNS inflammation in MS by inducing immunosuppressive myeloid cells and resolving inflammation.

bioRxiv · Jun 14, 2025 · PreprintNeuroscience