Yang Chen

The paper identifies two proteins, NosP and NosQ, that enable N2O reduction in acidic environments by protecting the NosZ enzyme from low pH.

This study maps the temporal transcriptomic changes in rhesus macaque neocortex during neurogenesis, revealing distinct lineage trajectories and signaling pathway divergence.

The paper introduces MINE, a toolkit to detect and analyze spatial density of regulatory chromatin interactions using Hi-C, ATAC-seq, and histone ChIP-seq data.

This study uses EpiGo-KRAB to introduce H3K9me3 at specific loci and shows it forms heterochromatin-like domains without widespread gene repression.

The paper shows MyoD organizes 3D genome architecture in muscle cells and demonstrates H3K27ac is insufficient for MyoD-induced chromatin loops.

The paper uses deep learning to identify phase-separated protein candidates from immunofluorescence images by classifying spherical droplet structures.

The paper identifies 3D genome alterations and enhancer hijacking mechanisms in T-lineage acute lymphoblastic leukemia (T-ALL) using integrated analyses of 18 patients and 4 controls.

SIP provides an interchangeable pipeline for scRNA-seq data processing, enabling easy integration and customization of analysis steps.