Yanru An

Single-cell spatial transcriptome reveals pathological features of human hippocampus with sclerosis

This study uses single-cell spatial transcriptomics to identify molecular and cellular changes in hippocampal sclerosis associated with MTLE, revealing vulnerable subregions and novel pathological features.

Applying high-resolution spatial transcriptomics to characterise the amyloid plaque cell niche in Alzheimer's Disease

This study compares two high-resolution spatial transcriptomics platforms in an AD mouse model to characterize the amyloid plaque cell niche and its cellular responses.

Single cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging and disease

The paper profiles spatial transcriptomic and translatomic data of dopaminergic neurons in young and old mice, identifying markers of aging and disease-related pathways, and highlights CASR as a novel regulator of dopaminergic calcium handling.

Single-cell transcriptional profiling reveals cellular and molecular divergence in human maternal-fetal interface

The paper uses single-cell transcriptomics to analyze cellular and molecular differences across maternal-fetal sections of the placenta, identifying key cell types and regulatory factors involved in placental development and preeclampsia.

High-resolution spatiotemporal transcriptomic maps of developing Drosophila embryos and larvae

This study uses Stereo-seq to generate high-resolution spatiotemporal transcriptomic maps of Drosophila embryos and larvae, revealing new subregions and gene regulatory networks.

A novel histone H4 variant regulates rDNA transcription in breast cancer

This study identifies H4G, a novel histone variant overexpressed in breast cancer tissues, which localizes to nucleoli and enhances rDNA transcription by destabilizing nucleosomes.