P. J. Michael Deans

This study investigates the phenotypic complexities of rare heterozygous NRXN1 deletions, showing cell-type-specific synaptic effects through LOF and GOF mechanisms, highlighting the need for precision medicine strategies.

This study identifies convergent biological pathways in mature neurons affected by neurodevelopmental disorder risk genes and shows drug candidates can ameliorate behavioral phenotypes.

The paper shows that schizophrenia hiPSC-derived NPCs have a reduced transcriptional response to IFN-gamma compared to controls, with implications for synaptic development and mitochondrial genes.

This study shows that NLGN3/4X clustering at growth cones promotes neuritogenesis and actin organization in immature human neurons, with ASD-associated variants lacking these effects.