Raúl Méndez

A common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice

This paper shows a CTRB2 deletion variant increases pancreatic cancer risk by causing ER stress and inflammation in mice, using a new genetic model.

Pathogenic mis-splicing of CPEB4 in schizophrenia

This study identifies aberrant CPEB4 splicing and downstream mis-expression of SCZ-risk genes as a novel etiological mechanism in schizophrenia.

A dynamic equilibrium between TTP and CPEB4 controls mRNA stability and inflammation resolution

The paper shows that CPEB4 and TTP regulate mRNA stability during inflammation resolution through competing polyadenylation and deadenylation, shaping the inflammatory response.

High concordance between hippocampal transcriptome of the intraamygdala kainic acid model and human temporal lobe epilepsy

The paper compares gene expression in a mouse model of status epilepticus to human temporal lobe epilepsy tissue, finding high concordance in gene dysregulation and shared molecular features.

Single cell 3'UTR analysis identifies changes in alternative polyadenylation throughout neuronal differentiation and in autism

The paper analyzes 3'UTR changes during neuronal differentiation and in ASD, finding longer 3UTRs in ASD patients and a role for CPEB4 and APLP1 in APA regulation.

Large-scale changes to mRNA polyadenylation in temporal lobe epilepsy

This study identifies widespread changes in mRNA polyadenylation in temporal lobe epilepsy, highlighting the role of CPEB4 in seizure severity and neurodegeneration.

Post-transcriptional regulation of adult CNS axonal regeneration by Cpeb1

This study identifies post-transcriptional regulation by Cpeb1 as a mechanism enhancing CNS axonal regeneration in mice and Drosophila.