Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas
Jessica D. St. Laurent, Grace Dydian Xu, Alexander Wang Ying, Bengul Gokbayrak, Ajinkya Patil, João A. Paulo, Kasey S. Cervantes, Shary Yuting Chen, William W. Feng, Akshay Sankar, Daniel D. Samé Guerra, Jun Qi, Dana S. Neel, Jason L. Hornick, David L. Kolin, , Cigall Kadoch
This study identifies shifted mSWI/SNF subcomplex stoichiometry in DDEC/UEC cancers and shows that SMARCA4/2 inhibitors reduce tumor growth and synergize with chemotherapy.
Nature Genetics · Oct 20, 2025Peer-reviewedMolecular Biology