Author

Jessica D. St. Laurent

Broad InstituteORCID 0000-0002-9422-8713Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Ajinkya PatiliD· 1 shared Akshay Sankar· 1 shared Alexander Wang YingiD· 1 shared Bengul GokbayrakiD· 1 shared Cigall KadochiD· 1 shared Dana S. NeeliD· 1 shared Daniel D. Samé GuerraiD· 1 shared David G. Hunstman· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Ajinkya PatilORCID

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1 paper

Recent·Most cited

Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas

Jessica D. St. Laurent, Grace Dydian Xu, Alexander Wang Ying, Bengul Gokbayrak, Ajinkya Patil, João A. Paulo, Kasey S. Cervantes, Shary Yuting Chen, William W. Feng, Akshay Sankar, Daniel D. Samé Guerra, Jun Qi, Dana S. Neel, Jason L. Hornick, David L. Kolin, , Cigall Kadoch

This study identifies shifted mSWI/SNF subcomplex stoichiometry in DDEC/UEC cancers and shows that SMARCA4/2 inhibitors reduce tumor growth and synergize with chemotherapy.

Nature Genetics · Oct 20, 2025Peer-reviewedMolecular Biology