Author

Kamesh Narasimhan

Harvard UniversityORCID 0000-0002-5065-1085Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2 Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:DNA methylation· 2 Organism:E. coli· 2 Research Focus:variant calling· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1

Frequent Co-Authors

George McDonald ChurchiD· 3 shared Jorge A. MarchandiD· 3 shared Anush Chiappino-PepeiD· 2 shared Bogdan BudnikiD· 2 shared John AachiD· 2 shared Ákos NyergesiD· 1 shared Azim M. DharaniiD· 1 shared Eleanor A. RandiD· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersSynthetic Biology

George McDonald ChurchORCID

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4 papers

Recent·Most cited

Preventing escape and malfunction of recoded cells due to tRNA base changes

Anush Chiappino-Pepe, Felix Radford, Bogdan Budnik, Hüseyin Taş, Teresa L. Augustin, Hana M Burgess, Michaël Moret, Azim M. Dharani, Qinmei Zheng, Weicheng Fan, Maksud M Africawala, Shova Thapa, Erkin Kuru, Kamesh Narasimhan, Jorge A. Marchand, , George McDonald Church

The paper shows recoded E. coli can escape faster due to tRNA base changes and introduces kill switches to prevent this.

bioRxiv · Jul 18, 2024 · PreprintSynthetic Biology

Swapped genetic code blocks viral infections and gene transfer

Ákos Nyerges, Svenja Vinke, Regan Flynn, Siân V. Owen, Eleanor A. Rand, Bogdan Budnik, Eric C. Keen, Kamesh Narasimhan, Jorge A. Marchand, Maximilien S. Baas-Thomas, Min Liu, Kangming Chen, Anush Chiappino-Pepe, Fangxiang Hu, Michael Baym, George McDonald Church

The paper demonstrates a genetic code reassignment strategy that makes cells resistant to viral infections and prevents horizontal gene transfer by mistranslating viral proteins and relying on synthetic codons.

bioRxiv · Jul 8, 2022 · PreprintSynthetic Biology

TBDB: A database of structurally annotated T-box riboswitch-tRNA pairs

Jorge A. Marchand, Merrick Pierson Smela, Thomas H. H. Jordan, Kamesh Narasimhan, George McDonald Church

TBDB provides a database of structurally annotated T-box riboswitch-tRNA pairs, offering the largest collection of sequence and structural annotations for this regulatory RNA family.

Nucleic Acids Research · Aug 21, 2020Peer-reviewedBioinformatics

Toward D-Peptide Biosynthesis: Elongation Factor P Enables Ribosomal Incorporation Of Consecutive D-Amino Acids

Po-Yi Huang, Fanny Wang, Kamesh Narasimhan, Kelly Chatman, John Aach, Sunia A. Trauger, Ryan Spoering, George M. Church

This study demonstrates that Elongation Factor P facilitates the ribosomal incorporation of consecutive D-amino acids by resolving peptidyl transferase stalling.

bioRxiv · Apr 10, 2017 · PreprintBiochemistry