Rachid El Fatimy

scDisentangle: sequential disentanglement for single-cell perturbation response prediction

scDisentangle predicts single-cell transcriptional responses to perturbations by decomposing expression into residual components, outperforming existing methods in cytokine stimulation, infection, and genetic perturbations.

CD160 is an inducible endothelial checkpoint that suppresses sprouting angiogenesis through LRP1-dependent autophagy

Neurotox: Deep learning decodes conserved hallmarks of neurotoxicity across venomous species

Neurotox identifies sequence-based neurotoxicity hallmarks across species using deep learning, showing structural changes correlate with loss of predicted neurotoxicity.

m6A modification and prion-like domain proteins converge to dysregulate Neuronal RNA Granules in Alzheimer s disease

This study identifies dysregulation of m6A modification and prion-like domain proteins in Neuronal RNA Granules as potential contributors to Alzheimer's disease pathogenesis.

Integrative Transcriptomic Profiling of NK Cells and Monocytes: Advancing Diagnostic and Therapeutic Strategies for COVID-19.

This study integrates transcriptomic data to identify key genes in NK cells and monocytes associated with immune dysregulation in COVID-19, highlighting potential biomarkers and therapeutic targets.

Astrocyte-to-microglia communication via Sema4B-Plexin-B2 modulates injury-induced reactivity of microglia

This study shows that Sema4B on astrocytes enhances microglia reactivity via Plexin-B2, contributing to CNS injury outcomes.

A nuclear function for an oncogenic microRNA as a modulator of snRNA and splicing

The paper shows miR-10b interacts with U6 snRNA, altering splicing and affecting cell viability through changes in CDC42 isoforms and levels.

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways

This study shows miR-132 protects neurons from tauopathy-related damage by regulating multiple pathways and reducing Tau pathology in mice.