Paul G. Collier

Transcript architecture sets the m6A landscape: CSTF2 and CSTF2T reshape m6A through cleavage-dependent and -independent mechanisms

The paper identifies CSTF2 and CSTF2T as factors that shape the m6A landscape through cleavage-dependent and -independent mechanisms by altering transcript architecture and polyadenylation sites.

Single-nuclei isoform RNA sequencing reveals combination patterns of transcript elements across human brain cell types

The paper introduces SnISOr-Seq, a method for single-nuclei isoform RNA sequencing, and finds distinct combination patterns of transcript elements in human brain cell types.

Patient-derived gene and protein expression signatures of NGLY1 deficiency

The paper characterizes gene and protein expression changes in NGLY1 deficiency using patient-derived cells and provides a web resource for the data.

BRN2 and PTN unveil multiple neurodevelopmental mechanisms in Schizophrenia patient-derived cerebral organoids

This study uses patient-derived cerebral organoids to identify molecular and cellular mechanisms of Schizophrenia, revealing altered neuronal programming factors and growth factors like BRN2 and PTN.

Extensive OMICS resource for Sf21 and Tni cell lines

The paper presents genome assemblies and gene predictions for Sf21 and Tni cell lines using multi-omics data, enabling improved use in protein expression and genome engineering.

Cell-type, single-cell, and spatial signatures of brain-region specific splicing in postnatal development

The paper identifies brain-region specific splicing patterns at single-cell and spatial resolution in postnatal mice, revealing cell-type specific and region-specific isoform expression.

Single-cell isoform RNA sequencing (ScISOr-Seq) across thousands of cells reveals isoforms of cerebellar cell types.

The paper introduces ScISOr-Seq, a method combining single-cell full-length cDNA amplification with short-read and long-read sequencing to identify isoforms in cerebellar cell types across thousands of cells.